Study of Biological Activity of Cobalt (II), Nickel (II), Manganese (II) Complexes With 8 -Hydroxyquinoline

Abstract

Cobalt (II), Nickel (II) and Manganese (II) complexes can be possessed biological activities, these complexes were synthesized via the reaction equimolar quantity of 8-hydroxyquinoline and saccharide such as (-) fructose and (+) glucose as a chiral secondary ligand with Cobalt (II) chloride hexahydrate {CoCl2.6H2O}, Nickel (II) chloride hexahydrate {NiCl2.6H2O} and Manganese (II) chloride tetrahydrate {MnCl2.4H2O} in ration(1:1:1) to form complexes [Co(HQ)(Glu)].2H2O (a) ,[Ni(HQ)(Fru)].2H2O (b), [Mn(HQ) (Glu)](c) respectively. The characterization of these complexes were follow by using Fourier Transform Infrared (FT-IR) and UV-Visible spectroscopy. Also a variable temperature study of these complexes has been followed by using UVVisible spectroscopy to follow electronic transform behaviors under temperature control also DFT study calculation was follow these complexes via the information from FT-IR and UV-Visible spectroscopy. A coordination number of these complexes of types five and six of the eometry can be suggested. These complexes were found to shown deferent inhibition to the growth of bacterial strains of (Staphylococcus aureus , Streptococcus , Escherichia coli , Klebsiella , Salmonella typhi , Sraphiaureus) while all complexes were in deferent's concentration (0.1 , 0.01 , 0.001M) and the result as evidenced from the presence. For better understanding these complexes were examined by using Density functional theory (DFT) calculation.